Colby Weeks

Assistant Professor


Mailing Address
Brigham Young University–Hawaii
Department of Biochemistry and Physical Science 
BYUH # 1967
55-220 Kulanui Street
Laie, Hawaii 96762  

Office: MCK 140E
Phone: (808) 675-3690
Fax: (808) 675-3825


PhD, University of California, Irvine, 2006



Bio220 & lab

Bio376 & lab

Bio442 & lab

All things microbiology!  I specialize in antimicrobial peptides, and have many projects exploring the antimicrobial activity of plants found on the island of Oahu.

Positive Selection of Arginine in α-Defensins: Attenuation of Bactericidal Activity by ArgLys Substitutions is Dependent on Peptide Primary Structure  Infect Immun. 2009 Nov; 77 (11):5035-43.

Weeks CS, Llenado RA, Cocco MJ, Young  S, Qu X, and Ouellette AJ


Anionic Amino Acids near the Pro-α-Defensin N-terminus Mediate Inhibition of Bactericidal Activity in Mouse Pro-Cryptdin-4 

J Biol Chem. 2009 Mar 13; 284 (11): 6826-21.

Figueredo S, Weeks CS, Young S, and Ouellette AJ


Matrix Metalloproteinase-7 Activation of Mouse Paneth Cell Pro-a-Defensins: Ser43Ile44 Proteolysis Enables Membrane Disruptive ActivityJ Biol Chem. 2006 Sep 29; 281 (39): 28932-42.

            Weeks CS, Hiroki T, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco M, and Ouellette AJ


Structure-Activity Determinants in Paneth Cell a-Defensins: Loss-of-Function in Mouse Cryptdin-4 by Charge-Reversal at Arginine Residue Positions.  J Biol Chem. 2004 Mar 19; 279 (12): 11976-83

            Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, and Ouellette AJ.